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About kalip

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    Food Ideas and Healthy Recipes Moderator
  • Birthday 12/20/1954

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    Jogging, Reading, Surfing the Internet , Meditation and travelling.

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    Suffered a heart attack in October 2001, Cardiologist prescribed, Aspirin, Simvastatin, and Coreg, all of which I am still using. Had two CYPHER® Sirolimus-eluting Coronary Stents inserted in my LAD artery in June 2004. Go jogging and walking on mornings from 5:00 am 5 days a week (Mondays to Fridays 8 km a day)
  1. How Safe Is it to Use A Public Bathroom? With dirty door handles, heavily trafficked toilet bowls, and proximity to strangers, public restrooms can be a germophobe’s worst nightmare. But the COVID-19 pandemic adds a new layer of risk, and infectious disease doctors are urging people to be cautious ahead of the holiday weekend. A recent study published in Physics of Fluids outlines the potential dangers of toilet plumes -- clouds of droplets that can rise 3 feet from a flushing toilet and be inhaled by an unsuspecting user. Aside from the obvious ick factor, simulations found that coronavirus remnants in a person’s stool can make their way onto other surfaces or linger in the air nearby. But there are things people can do to avoid the dangers of restrooms. “What’s the most hazardous part of using a public restroom? It’s the people in it,” says William Schaffner, MD, a professor of medicine in the Division of Infectious Diseases at the Vanderbilt University School of Medicine. “It’s not necessarily the inanimate environment.” Wear a mask, of course. Scope out the bathroom ahead of time to see how congested it is, Schaffner says, and wait to use it until it has cleared out a bit. If it is urgent, try to keep your distance from people -- for men, stay a couple of urinals away from the nearest person. Aim to use larger restrooms to avoid close contact with people and toilet sprays. Though it may be tempting to use seat covers, it is not recommended -- they could be covered with their own germs, and it is smart to keep contact with objects to a minimum. “If you want, you can carry wipes into the bathroom with you and wipe off the toilet seat before sitting down,” Schaffner says. Toilets with lids can be closed before flushing to avoid the plume. If they don’t have lids, back away and exit the stall as quickly as possible. And when approaching the sink for hand-washing, Schaffner says, pay attention to the number of people already using the space. If you can, wait until the area is clear. Although studies have shown that high-powered air dryers can blow harmful particles around, infectious disease experts say those machines and paper towels have similar risks. In fact, Schaffner says, the air dryers might be safer. “I think air dryers help rather than hurt -- they move air around,” he says. “If there happens to be a person next to you that's infected, the air dryer will disperse the air, and you're much less likely to get an infectious dose of the virus.” According to Aaron E. Glatt, MD, chairman of medicine at Mount Sinai South Nassau, the risk of contact with bodily fluids pales in comparison to the dangers of close gatherings. After all, there is always a chance of plume contamination with viruses and bacteria like E. coli. “Bodily fluids are always a concern, regardless of COVID,” he says. Glatt’s main advice? Be smart and use common sense. If you are going on a trip, try to avoid using a public restroom altogether and go before you leave the house. The bigger concern, Glatt says, is the potential spike of COVID-19 cases after fireworks displays and barbeques bring large groups of people together. “People aren't being careful. We're seeing it across the country right now,” he says. “This is a formula for disaster.” As long as people are mindful of “the big three” -- masks, hand-washing, and distancing -- the country can avoid a post-holiday spike, Schaffner says. “There is still plenty of room for people to enjoy themselves,” he says. https://www.webmd.com/news/default.htm kalip
  2. Getting Your Protein From Plants a Recipe for Longevity Swapping out tofu for your morning eggs or using beans instead of ground beef in your chili could help you live longer, a new study report. Getting your daily protein from plants instead of animals appears to reduce your overall risk of early death, researchers found. Every 3% of a person's daily energy intake coming from plant protein instead of animal protein reduced a person's risk of premature death by 10%, the results showed. The results were particularly strong when people swapped plant protein for eggs (24% lower risk in men and 21% lower risk in women) or red meat (13% lower risk in men, 15% in women). Taking red meat out of your diet can be beneficial, but only if you swap for a healthy substitute, said lead researcher Jiaqi Huang, a postdoctoral fellow at the U.S. National Cancer Institute. "For example, replacement of 3% energy from egg protein or red meat protein with plant protein such as whole grains or cereals resulted in a protective association for overall mortality," Huang said. "On the other hand, replacement of 3% energy from egg protein or red meat protein with other foods such as sugar-sweetened beverages may or may not result in a reduction in mortality." For this study, Huang's team analysed dietary data from more than 237,000 men and 179,000 women gathered between 1995 and 2011 as part of a long-term study on eating patterns and health. Protein made up about 15% of people's daily diet, with 40% coming from plants and 60% from animals, the researchers found. During 16 years of follow-up, a pattern emerged where plant protein intake appeared to reduce risk of early death. Every 10 grams of plant-for-animal protein swapping per 1,000 calories resulted in a 12% lower risk of death for men and 14% for women, the findings showed. According to senior researcher Dr. Demetrius Albanes, a senior investigator with the cancer institute, "Our data provide evidence to support the favourable role for plant-based diets in the prevention of cardiovascular disease mortality, and that modifications in choices of protein sources may influence health outcomes and longevity." There are many reasons why choosing plant protein over animal protein could help extend your life, the researchers and experts said. Meat protein tends to come with higher levels of saturated fat, cholesterol, sodium and other nutrients that aren't very good for your health, said Connie Diekman, a food and nutrition consultant in St. Louis and a past president of the Academy of Nutrition and Dietetics. "For example, one ounce of red meat mixed with whole wheat pasta and veggies would provide much less saturated fat than a 9-ounce steak," Diekman said. On the other hand, plant proteins come with loads of fibre, antioxidants, vitamins and minerals, said Kayla Jaeckel, a registered dietitian and diabetes care manager with Mount Sinai Health System in New York City. The researchers also added that there might be something specific about the amino acids formed from the breakdown of animal-based protein that could cause arteries to grow harder or inflammation to occur. Animal protein also could affect the health of people's gut bacteria. One weakness of the study is that it relied on people's memories, as they were asked to remember what they'd eaten and fill out a questionnaire, Diekman said. "This provides a glimpse at diet intake but doesn't show patterns, and patterns are key," Diekman said. "Combining an egg with brown rice and veggies provides a very different nutrient intake than eggs, bacon, biscuits and gravy." These findings also run counter to other recent studies that have shown eggs are healthier than folks believed for decades, Jaeckel said. "I think eggs can be part of a healthy and balanced diet. I wouldn't want eggs to be painted in a negative light, because I feel like there's always been flip-flopping with them," Jaeckel added. Diekman said, "My take on the study, and what I would tell clients, is that evidence continues to grow to support the importance of consuming more plant foods and less animal foods, while also boosting vegetable, whole grain and fruit intake. We can enjoy our favourite, heavy egg or meat dish but probably not every day, and preferably in balance with lots of plant foods." The report was published online July 13 in JAMA Internal Medicine. More information The American Heart Association has more about healthy eating. https://consumer.healthday.com/ kalip
  3. COVID-19 May Spike Blood Sugar, Raising Death Risk Bodies stressed by severe COVID-19 could produce abnormally high blood sugar levels, even in people without diagnosed diabetes. And that appears tied to a doubling of the odds of dying from COVID-19, Chinese researchers report. High blood sugar (glucose) levels, measured at the time of admission to the hospital, were also linked to more severe disease and complications, according to researchers led by Dr. Yang Jin, of the Union Hospital and Tongji Medical College, in Wuhan, China. Wuhan was the originating epicentre of the global pandemic of COVID-19. As the researchers explained, diabetes has long been known to greatly raise the odds for severe and even fatal COVID-19 in people infected with the new coronavirus. But what about the effect of high blood sugar levels, even in people who don't have a diabetes diagnosis? To find out, Jin's group looked over the medical records of more than 600 consecutive patients treated at two Wuhan hospitals for nearly a month in January and February. Patients averaged 59 years of age. The researchers looked especially at each patient's blood sugar readings, the severity of their COVID-19-linked pneumonia, and patient outcomes in terms of illness severity and death. None of the patients had been diagnosed with diabetes. A total of 114 patients died in the hospital from their illness, Jin's team said. Men were 75% more likely to die than women. A high level of fasting blood glucose was found to be highly predictive of death, the researchers reported July 10 in the journal Diabetologia. That held true "regardless of whether the patient has [COVID-19-linked] pneumonia that is more or less severe," the team said -- suggesting that the effect of high blood sugar on the death risk is independent of just how severe the patient's respiratory illness might be. Of the total patient group, about one-third (29%) fell into a category of very high fasting blood glucose -- so high that, if consistent over time, these patients would be diagnosed with having type 2 diabetes. Another 17% had levels that were similar to people in "pre-diabetes." Patients in the very high blood sugar category were 2.3 times more likely to die of COVID-19 than those with the lowest blood sugar readings, the study showed, and even those with readings suggestive of pre-diabetes had a 71% higher risk of death. The odds for dangerous complications of COVID-19 were also four times higher in people in the high blood sugar category, and 2.6 times higher in those with a pre-diabetes level of blood sugar, the Chinese team said in a news release from the European Association for the Study of Diabetes. Diabetes expert Dr. Minisha Sood is an endocrinologist at Lenox Hill Hospital in New York City. Reading over the new study, she noted that even in non-diabetic people, blood sugar levels can spike in response to serious illness. "The rise in blood sugar due to an illness is called stress hyperglycaemia," she explained. "The body, under stress, produces hormones and a reaction to the illness which elevates blood glucose." However, such spikes typically don't happen in previously healthy individuals, Sood noted. "The higher blood glucose in patients who ultimately succumb to COVID-19 versus other patients with normal blood glucose despite a COVID-19 infection may be a sign that their underlying systems are not as healthy as those who do not have stress hyperglycaemia," she said. According to the Chinese authors, stress hyperglycaemia may indeed have stricken many of the Wuhan patients, since the 29% of patients who landed in the highest blood sugar group "is much higher than the estimated prevalence of diabetes in the Chinese population at 12%." Based on the findings, the study authors advised that close tracking of blood sugar levels be added to the list of tests that doctors use to monitor risks for patients battling COVID-19. Sood agreed. "The bottom line is that everyone will respond to illness in their unique way," she said, "and it would be helpful to have ways to predict who may have a worse outcome from a COVID-19 infection. Having a high blood glucose on admission to the hospital may be one of those predictive measures. https://consumer.healthday.com/ kalip
  4. Forgiveness and the Power of Letting Go Learning to forgive doesn't always come easy, and it's a patient and tender process. Many times, forgiveness can feel more like a weakness than an act of courage and strength. Let's explore how elevating awareness around this powerful act can be a catalyst toward greater health—physically, mentally, and spiritually—while helping to transform your family, community, and country. Good health and nourishment aren't just about the vitamins and minerals you ingest; it's also who you are as a human being. What Is Forgiveness? In simple terms, forgiveness is a choice you make to give up anger or resentment, even while acknowledging that the wrongdoing happened. It's not so much behaviour as it is an internal state of feeling and being. Forgiveness is choosing a higher path and moving through a process of letting go that's not so much about the other person, but your process. Taking it a step further, Bob Enright, Ph.D. at the University of Wisconsin, Madison, describes true forgiveness as offering something positive: "Empathy, compassion and an understanding towards the person who hurt you," making it both a virtue and a robust framework in positive psychology. It's also important to acknowledge that forgiveness is not pardoning, excusing, forgetting, condoning, or even accepting bad behaviour. It's a gift of freeing yourself from anger. As described in Psychology Today, forgiveness is ultimately about "freeing ourselves from feelings of anger, resentment, and victimisation, and ending with clarity about our values." Why Forgive? "There is an enormous physical burden to being hurt and disappointed," says Karen Swartz, M.D., director of the Mood Disorders Adult Consultation Clinic at The Johns Hopkins Hospital. And forgiving is an active process—like learning to ride a bicycle—it's a skill that takes time and gets better with practice. Studies are finding connections between forgiveness and physical, mental, and spiritual health and evidence that it plays a vital role in the health of families, communities, and nations. In the book Forgiveness and Health, doctors Loren Toussaint and Everett L. Worthington show in their research that "forgiveness is linked to mental health outcomes such as reduced anxiety, depression and major psychiatric disorders, and fewer physical health symptoms and lower mortality rates." The connection between forgiveness and mental and physical health and well-being suggests stress relief as the primary factor connecting forgiveness and well-being. Neda Gould, a clinical psychologist at Johns Hopkins University, explains, "Anger is a form of stress, and so when we hold on to anger it is as though we are turning on the body's stress response, or fight or flight response, chronically." You are probably aware of the impact of chronic stress and its adverse effects on the body. Amazingly, the act of forgiveness can help release the relational stressors that weigh you down, also helping to reduce blood pressure impacting your cardiovascular health. Forgiveness also has benefits such as higher self-esteem, better moods, and happier relationships, according to the Greater Good Science Centre. How to Forgive When it comes to forgiveness, there's no silver bullet or quick fix to finding peace of mind. And everyone responds differently to various interventions that help people move through the forgiveness process, which is associated with positive outcomes. Learning to forgive is highly unique to each individual. Below are ways Dr. Schwartz suggests for integrating it into your daily life if one chooses: Reflect and Remember: Recall the events, your reactions to them, and the feelings. How has hurt and anger impacted you? Empathise with the Other Person: Empathy can be described as an “imagine-other” perspective, which focuses on the experiences of another person, according to PsychCentral. It is a way of being present to someone and feeling into their experience. Forgive Deeply: Dr. Schwartz says people who forgive from a place of understanding and realise that no one is perfect can return to a normal relationship with the other person, even if that person never apologised. Let Go of Expectations: Saying you're sorry may not shift your affiliation with another person or bring forth an apology; however, if neither is expected, you won't be disappointed. Decide to Forgive: Dr. Schwartz explains when you choose to forgive, "Seal it with an action." If you're not able to communicate with the person who hurt you, journal, or write about your forgiveness. Try talking about it with a counsellor or therapist or someone else in your life who you trust. Forgive Yourself: Cultivating self-forgiveness can be a challenge, and learning to be kind to yourself is another skill that requires practice and deserves your full, most-dedicated, and gentle attention. Your shortcomings are as much a part of your humanity as your individual strengths. Learning to practice self-kindness is an important and critical practice for your well-being. By committing to a self-kindness practice, "We can learn to become more constructive and effective in accepting and rectifying our errors - and, in the process, grow as individuals," according to Carole Pertofsky, MEd, director emerita of student wellness services at Stanford. Nourishment and Healing Forgiveness is a choice you make over and over again. Both forgiveness and letting go are forms of nourishment that help you grow as an individual, and as a collective. In learning about, and moving into a process of forgiveness, you will see it isn't about giving up—it's about moving into an understanding that the best is yet to come—and nearly everyone can benefit from moving forward in that context. I wish you a regular and healthy dose of vitamin “F” as you continue along your journey to health and healing. https://chopra.com/ kalip
  5. Coronavirus: Spanish study casts doubt on herd immunity feasibility A Spanish study has cast doubt on the feasibility of herd immunity as a way of tackling the coronavirus pandemic. The study of more than 60,000 people estimates that around just 5% of the Spanish population has developed antibodies, the medical journal the Lancet reported. Herd immunity is achieved when enough people become infected with a virus to stop its spread. Around 70% to 90% of a population needs to be immune to protect the uninfected. The prevalence of Covid-19 antibodies was below 3% in coastal regions, but higher in areas of Spain with widespread outbreaks, the report said. Despite the high impact of Covid-19 in Spain, prevalence estimates remain low and are clearly insufficient to provide herd immunity," the study's authors said in the report. "This cannot be achieved without accepting the collateral damage of many deaths in the susceptible population and overburdening of health systems. "In this situation, social distance measures and efforts to identify and isolate new cases and their contacts are imperative for future epidemic control." The study is thought to be the largest of its kind on the coronavirus in Europe. There have been studies of a similar kind in China and the US and "the key finding from these representative cohorts is that most of the population appears to have remained unexposed" to the coronavirus, "even in areas with widespread virus circulation," the Lancet article said. Prof Danny Altmann, British Society for Immunology spokesperson and Professor of Immunology at Imperial College London, described the study as "sobering". "Findings such as this reinforce the idea that faced with a lethal infection that induces rather short-lived immunity, the challenge is to identify the best vaccine strategies able to overcome these problems and stimulate a large, sustained, optimal, immune response in the way the virus failed to do," Prof Altmann said. What's the latest in Spain? The country has recorded more than a quarter of a million cases and at least 28,385 deaths. But daily fatalities have been in the single figures for most of the past three weeks. However, officials in the north-western region of Galicia have re-imposed restrictions on an area of 70,000 people following an outbreak. Officials linked local outbreaks to bars in the area. Capacity in bars and restaurants have been limited to 50%. There are now 258 cases of Covid-19 in Galicia, including 117 in Lugo province, authorities say. On Saturday the autonomous government of Catalonia re-imposed controls on an area of 210,000 residents after a sharp rise in infections there. Catalan President Quim Torra said no-one would be allowed to enter or leave Segrià, a district west of Barcelona that includes the city of Lleida The search for a fit response Herd immunity can be reached either by widespread vaccination or if enough of the population is exposed to an infection and recovers. If enough people are immune to a disease, it is unlikely to keep spreading from person to person. Letting the coronavirus infection run and risking lots of people getting very sick with it is not an option - it would put too many lives in danger. And currently, there is no vaccine for coronavirus - even though hundreds are in development. The challenge is to make a jab that provides enough protection. It needs to train the body's immune system to learn and remember how to make antibodies that can fight off coronavirus. Scientists are concerned that this "memory" might be too short-lived though, given the nature of the disease. While some people who catch coronavirus develop protective antibodies, experts do not yet know how long these last. Common colds are caused by similar viruses and the body's immune response fades quickly to those. https://www.bbc.com/news/health kalip
  6. BBQ Tempeh Vegan Ribs Ingredients 1 pkg Tempeh (12 oz) 2 Tbs Apple Juice 2-3 Tbs BBQ Rub 2 cups Hickory Wood Chips (for outdoor smoking) BBQ Rub 1/4 cup Paprika 2 Tbs Kosher Salt 2 Tbs Chili Powder 2 Tbs Brown Sugar 1 Tbs Black Pepper 2 tsp Garlic Powder 2 tsp Onion Powder 1/2 tsp Cayenne Pepper (or more to taste) Instructions If using outdoor grill or smoker: Soak Hickory Wood Chips in water for at least 30 minutes. Prepare ribs by slicing Tempeh into 6" long strips about 1" wide. Brush ribs with Apple Juice and then liberally apply rub working it into all the nooks and crannies of the Tempeh. Place ribs on grate as far away from the coals as possible (indirect-heat). Add a handful of soaked Hickory Chips to coals and allow Tempeh to smoke in low-heat (122 °C) for 1 hour. Occasionally add more chips to coals for a smokier flavour. Additionally, spritz (or brush) Apple Juice on ribs occasionally to keep them from drying out. Finally, move the ribs down to the direct heat and slather with your favourite BBQ sauce. Cook for 1-2 minutes per side, turn and apply more sauce until a nice crust or bark is formed. Serve with your favourite BBQ Sides, like my Coleslaw or Potato Sala Servings: 3 https://www.brandnewvegan.com/recipe-index kalip
  7. Face Shields May Be Next Step to Prevent COVID Face masks have become commonplace in the effort to combat COVID-19, but some doctors say it is time to take protection a step further and try full face shields as restrictions slowly begin to loosen. Face shields are nothing new in medical settings -- doctors and nurses who treat coronavirus patients are using them along with standard face masks. Health care professionals are split on whether they should also be worn by children, teachers, and in offices while states reopen. “Face shields appear to have a number of advantages: They’re easy to wear correctly and good at blocking droplets,” says Eli Perencevich, MD, an infectious disease doctor at the University of Iowa and the Iowa City Veterans Affairs Health Care System. “They’re really a better option for protection.” Perencevich and his colleagues published a report in JAMA last month, arguing that face shields have more COVID-fighting potential than standard masks when used with increased testing, contact tracing, and social distancing. A few things make shields superior; he says. For one, many people wear masks that don’t fit well, so they don’t work as well. They also prompt people to touch their faces more, increasing the risk of viral spread. They leave much to be desired in terms of comfort, he says, and they make it harder to breathe. Shields come with the perk of being easily sanitised and reused, says Keith Kaye, MD, a professor of medicine and director of research for the division of infectious diseases at the University of Michigan Medical School. Unlike masks, clear shields also allow for better communication -- people can read facial expressions, and those who are hearing impaired can read lips, he says. “I do think we're going to see more and more face shield use,” Kaye says. “Particularly as COVID continues to cause problems.” While there is not a lot of data on how well masks work, one recent study in China found that wearing a mask at home reduced transmission to other members of the same household by nearly 80%. Shields, meanwhile, have been found to successfully block droplets. One cough simulation study in 2014 found that a shield may reduce exposure by 96% when worn within 18 inches of someone coughing. In addition, face masks are not meant to protect the wearer -- they leave other vulnerable parts of the face exposed, like the eyes. They are meant to keep an asymptomatic or pre-symptomatic person from spreading it to others. But not all doctors are sold on everyday use of more extreme protective gear. Dan Kuritzkes, MD, chief of infectious diseases at Brigham and Women’s Hospital in Boston, says the eye coverage that shields provide is likely not necessary for people unless they are providing medical care to COVID-19 patients. “In theory, it may be possible that particles could land in someone’s eye and cause infection, but we don’t have good evidence that happens,” he says. “I think the bottom line is for the general public, there's no reason to be wearing face shields.” He also says they may not help prevent airborne transmission, because air that has droplets in it could get sucked under the shield from the bottom opening. Face shields are important in health care settings because, in those situations, mucous membranes around the caregivers’ eyes that could come into contact with harmful droplets while they do procedures like intubation, says Timothy Brewer, MD, a professor of medicine and epidemiology at the UCLA Fielding School of Public Health and Medicine. As long as everyone abides by recommendations to wear a face mask, that risk won’t exist for non-health care workers. “It could potentially get in someone’s eyes if someone sneezes -- that's why the person sneezing should also be wearing a mask,” Brewer says. Meanwhile, other parts of the world are embracing the use of face shields outside of hospitals. School children in Singapore are being given face shields as they head back to classes in the coming days. The Infectious Diseases Society of America has listed widespread use of protective gear, including face shields, in the process of lifting restrictions, but the CDC still recommends just face masks for people outside the health care realm. Still, people and companies have jumped in to help supply shields to both health care workers and other people at higher risk of catching the virus. Amazon announced this month that its engineers are developing face shields to sell on its site after donating almost 10,000 to people on the front lines. Other efforts have come from everyday citizens. Katherine Marcano-Bell and her family have converted part of their 1,300-acre pig farm into a shield-making operation, and have delivered them to hospitals, clinics, meatpacking plants, and families who have made specific requests for them. “I think it wouldn't hurt to wear one, especially if you're sick or immunocompromised,” Marcano-Bell says. https://www.webmd.com/ https://jamanetwork.com/journals/jama/fullarticle/2765525 kalip
  8. Make These Vegan Tempeh Spring Rolls With Peanut Sauce Ingredients Tempeh: 1/2 block tempeh (113g) thinly sliced 1/4 cup coconut aminos (60ml) 2 tsp chili garlic sauce (5ml) 2 tsp minced ginger (5g) 1 tsp minced garlic (3g) Peanut Butter Sauce: 1/4 cup peanut butter 3 tbsp coconut aminos 45ml 2-3 tbsp water 1 tbsp sriracha 15ml 1 tsp seasoned rice vinegar 5ml 1 tsp agave nectar 1/4 tsp garlic powder 1/8 tsp ginger powder Summer Rolls: Vietnamese rice paper (six) lettuce 36g Shredded Red cabbage 125g 2 sliced Green onions sliced Yellow bell pepper 120g grated carrots 120g cucumber batonnets (sliced lengthwise) 180g Instructions Tempeh: Slice the half tempeh block in thin slices lengthwise. In a small bowl, combine the tempeh and the marinade ingredients. Mix to coat the tempeh well. Heat a pan on medium-low heat, add the tempeh and the rest of the marinade to the pan. Cook until the tempeh is browned on both sides. About 10-15 mins. Peanut Butter sauce: Combine ingredients and whisk until smooth. Set aside. Summer Rolls: Fill a large bowl with water. Immerse one wrapper in the water to soften. Pull it out, being careful so it doesn't collapse on itself, and lay it on a cutting board. Fill the wrapper with the veggies, a few pieces each, add three slices of tempeh. Fold the top and bottom of the wrapper over the filling. Fold the left&right sides, and roll tightly. Repeat with remaining rice papers. Makes six rolls. Slice in half to serve, if desired. https://www.livekindly.co/vegan-food/ kalip
  9. Drug Combos May Be Advance Against Heart Failure Many patients with heart failure might live years longer if they were on a combination of newer medications, a study suggests. Researchers estimate that if certain heart failure patients were prescribed a four-pill regimen -- including three recently proven therapies -- they could live up to six years longer, compared with the regimen patients commonly use. The findings, published online recently in the medical journal The Lancet, are projections, not guarantees. But they do make a strong case for the medication cocktail, said lead author Dr. Muthiah Vaduganathan, a cardiologist at Brigham and Women's Hospital in Boston. "Combined use of these four pills would be anticipated to keep patients out of the hospital and alive for more years," he said. Heart failure is a chronic condition in which the heart muscle cannot pump blood efficiently enough to meet the body's demands -- causing symptoms such as fatigue, breathlessness and leg swelling. The new study focused on patients who had heart failure with reduced ejection fraction, which refers to how much blood the heart pushes out with each contraction. Reduced ejection fraction affects about half of heart failure patients. For a long time, the standard medication regimen for those patients was a beta blocker plus an ACE inhibitor or an angiotensin II receptor blocker (ARB). All three drugs lower blood pressure and ease the heart's workload through different mechanisms. But more recently, clinical trials have found that three other drug types can help patients live longer, beyond standard drugs alone. One is a medication called Entresto, which combines the ARB valsartan with another drug, sacubitril. Another is a diabetes drug called dapagliflozin (Farxiga), which was recently shown to benefit heart failure patients with or without diabetes. The third drug class is actually an old one: mineralocorticoid receptor antagonists, which include spironolactone and eplerenone. They help control blood pressure by blocking a hormone called aldosterone. Despite the positive findings, though, many doctors still do not prescribe those drugs for heart failure, Vaduganathan said. And there is little evidence on what would happen if patients used all three types of medication. "The optimal combination really hasn't been studied," Vaduganathan said. So his team tried to estimate the benefits of taking the newer therapies, together, over many years. To do that, they combed shorter-term data from three large clinical trials that tested the drugs against standard treatment. Then they made some projections: What would happen if patients started on a beta blocker plus the three drug classes, instead of an ACE inhibitor or ARB -- and stuck with the regimen for the long haul? For a 55-year-old, the researchers estimate, that could translate into an extra six years of life, and eight years free of hospitalisation for heart failure. For an 80-year-old, the benefits would be smaller but still important -- an extra year of life, on average, and nearly three extra years out of the hospital. In an "ideal world," all eligible patients would be on the medications, said Dr. Mary Norine Walsh, past president of the American College of Cardiology. "But here's the rub," she added. "Two of these drugs [Entresto and Farxiga] are not available as generics." So, many patients may be unable to afford the pricey medications, even with insurance. Farxiga costs roughly $500 for 30 pills, while Entresto costs about $600 for 60 pills, according to an online search. Beyond cost, not all patients should be on the drugs. Walsh, who was not involved in the study, stressed that the findings apply only to patients with reduced ejection fraction -- which leaves out half of people with heart failure. And any one patient, she said, might have other health issues that are contraindicated for a given drug. "There may be reasons not to take a medication," Walsh said. "But that shouldn't stop patients from asking their doctor questions." Specifically, she said, patients who are still on an ACE inhibitor or ARB can ask their doctor why they have not been switched to Entresto -- which guidelines say is the preferred choice. The diabetes drug Farxiga was only just approved for treating heart failure with reduced ejection fraction, Vaduganathan noted. So, it's not yet included in treatment guidelines. The study received no funding, but the researchers report connections to various drug companies that make heart failure medications. More information The American Heart Association has more on heart failure treatment. Healthday. kalip
  10. Another COVID-19 vaccine candidate has achieved good early results, a research team in China reported Friday. The experimental vaccine produced important signs of immune response in a small group of adults, a sign that it could potentially protect people against COVID-19, researchers reported May 22 online in The Lancet medical journal. "These results represent an important milestone," researcher Wei Chen, part of a team with the Beijing Institute of Biotechnology, said in a journal news release. "However, these results should be interpreted cautiously," Chen continued. "The challenges in the development of a COVD-19 vaccine are unprecedented, and the ability to trigger these immune responses does not necessarily indicate that the vaccine will protect humans from COVID-19." This particular vaccine candidate used a weakened common cold virus called an adenovirus to safely deliver COVID-19 coronavirus genetic material into human cells. This causes the body to produce the "spike" protein that the coronavirus uses to invade human cells. In turn, the immune system responds to the presence of the protein by creating antibodies that potentially could fight off future coronavirus infections, the researchers said. Within a month, most of the 108 healthy adult participants in the phase 1 trial had a fourfold increase in binding antibodies. These antibodies can bind to the coronavirus, but don't necessarily attack it. Half of the participants who received low or moderate doses and three-quarters of those who received a high dose also developed neutralising antibodies, which can protect the body against the coronavirus, researchers reported. "Not only did the virus induce antibodies but also T-cell immunity, which will also be important for confirming protection," said Dr. Amesh Adalja, a senior scholar with the Johns Hopkins Centre for Health Security, who called the trial results "very welcome." However, Adalja said the vaccine's use of a common cold virus to deliver its genetic payload could hamper its effectiveness. "Adenoviruses are very common and there are many people with pre-existing immunity," Adalja said. "In a prior trial using this type of platform for HIV vaccination, there was a paradoxical increase in risk of infection in those who are vaccinated who had pre-existing adenovirus 5 immunity. Whether this phenomenon is present with this vaccine will be important to investigate in detail in phase 2 and phase 3 trials." There was some evidence of this in the clinical trial, with people who had existing cold virus immunity showing a reduced immune response to the vaccine, the Chinese researchers noted. A full-fledged phase 2 trial has been initiated in Wuhan to see if the results can be replicated in 500 healthy adults, which would include 250 volunteers given a moderate dose, and another 250 given either a low dose or a placebo. The U.S. Department of Health and Human Services has entered a full-court press to develop potential COVID-19 vaccine candidates. U.S. federal officials said Thursday the agency would provide up to $1.2 billion to the drug company AstraZeneca to develop a potential coronavirus vaccine from a lab at the University of Oxford in England. The fourth, and largest, vaccine research agreement funds a clinical trial of the potential vaccine in the United States this summer with about 30,000 volunteers, the New York Times reported. The goal? To make at least 300 million doses that could be available as early as October, the HHS said in a statement. However, many experts have said that the earliest an effective, mass-produced vaccine would be available won't be until sometime next year, and billions of doses would be needed worldwide. The United States has already agreed to provide up to $483 million to the biotech company Moderna and $500 million to Johnson & Johnson for their vaccine efforts. It is also providing $30 million to a virus vaccine effort led by the French company Sanofi, the Times reported. More information The U.S. Centres for Disease Control and Prevention has more on COVID-19. https://consumer.healthday.com/ kalip
  11. SPICY TOFU AND MEATY MUSHROOM VEGAN KOREAN BBQ STIR-FRY Ingredients 2 white potatoes peeled and cubed 1 cup of soy sauce 1/4th white onion diced 1/2 cup freshly chopped cilantro 1 cup of snow peas 3 cups pre-cooked brown rice ½ red pepper diced ½ green pepper diced ½ poblano pepper diced 2 cups broken up broccoli florets 1 carrot diced ½ cup white button mushrooms 1 pack of firm tofu drained and cubed 2 tablespoons of coconut oil ½ cup of slivered almonds Korean BBQ Sauce Ingredients: 1 cup soy sauce 1/2 cup brown sugar 1 tablespoon of rice vinegar 1 clove of garlic 2 table spoons of toasted sesame oil 1 tablespoon black pepper 1 teaspoon tapioca flour 1 teaspoon ground ginger Instructions Combine ingredients to make Korean bbq sauce into blender and blend until smooth. Put chopped potatoes and tofu in a large mixing bowl. Add 1 cup of Korean bbq sauce and ¼ cup chopped cilantro. Massage mixture into potatoes and tofu vigorously for 5 minutes. Let stand for another 10 minutes. Sauté potato and tofu mixture for 10 minutes until browned on each side. Add in the rest of your pre-cut veggies. Then sauté with coconut oil, 1 cup of soy sauce and the remainder of your Korean BBQ mixture until veggies are tender yet firm. Spoon 1 cup of stir fry on you plate and top with a tablespoon of silvered almonds. Nutrition Facts Spicy Tofu and Meaty Mushroom Vegan Korean BBQ Stir-Fry Serves: 8 Amount Per Serving Calories 162 % Daily Value* Total Fat 9.5 grams 14.6% Saturated Fat 0 Trans Fat Cholesterol 0 Sodium 329 milligrams 13.7% Total Carbohydrate 11 grams 3.7% Dietary Fiber 0 Sugars 3.5 grams Protein 12 grams Vitamin A Vitamin C Calcium Iron * Percent Daily Values are based on a 2,000 calorie diet. Your daily values may be higher or lower depending on your calorie needs. https://www.livekindly.co/vegan-food/vegan-recipes/ kalip
  12. As some countries ease up, others are reimposing lockdowns amid a resurgence of coronavirus infections As many parts of the world, including the United States, explore ways to ease restrictions aimed at containing the spread of the coronavirus, countries that had already opened up are closing down again after renewed spikes in infections. Such a resurgence of cases had been widely predicted by experts, but these increasing numbers come as a sobering reminder of the challenges ahead as countries chafing under the social and economic burdens of keeping their citizens indoors weigh the pros and cons of allowing people to move around again. Lebanon on Tuesday became the latest country to reimpose restrictions after experiencing a surge of infections, almost exactly two weeks after it appeared to have contained the spread of the virus and began easing up. Authorities ordered a four-day, near-complete lockdown to allow officials time to assess the rise in numbers. The re-emergence of coronavirus cases in many parts of Asia is also prompting a return to closures in places that had claimed success in battling the disease or appeared to have eradicated it altogether, including South Korea, regarded as one of the continent’s top success stories. South Korea last week rescinded a go-ahead for bars and clubs to reopen after a spike in cases, hours after officials announced the lifting of previous social distancing restrictions and the start of a “new everyday life with the coronavirus.” South Korean President Moon Jae-in warned his country Sunday to “brace for the pandemic’s second wave,” calling the battle against covid-19 a “prolonged” fight. In the Chinese city of Wuhan, where the pandemic first emerged, authorities on Tuesday ordered the testing of all 11 million inhabitants after a cluster of six new infections emerged, five weeks after the city had apparently rid itself of the disease. Germany, which is widely regarded as the model in Europe of a balanced coronavirus response, is warning that some areas may have to reinstate restrictions after localised outbreaks caused a rise in cases. “We always have to be aware that we are still at the beginning of the pandemic,” German Chancellor Angela Merkel cautioned last week as a cluster of new cases in a meatpacking plant raised fears of an intensified outbreak. “And there’s still a long way in dealing with this virus in front of us.” Some countries are going ahead with plans to lift restrictions despite evidence that cases are on the rise and the disease is far from being contained. India and Russia eased their restrictions Tuesday even as the number of infections in both countries continued to soar. Iran, the epicentre of the disease in the Middle East, with more than 110,000 reported cases, has ordered a county in the southwestern province of Khuzestan to reimpose a lockdown after cases spiked there. But the government is still planning to proceed with the reopening of schools later this week, despite a marked jump in new infections since restrictions were eased in late April. The new spikes underscore the question of when — or whether — it will ever be fully safe for coronavirus-stricken countries to lift their lockdowns. The latest cluster in Wuhan demonstrates how hard it will be to measure whether any location is truly free of coronavirus. The new cases there suggest the virus can flare up in patients up to 50 days after they have apparently recovered, said Wu Zunyou, chief epidemiologist at the Chinese Centre for Disease Control and Prevention, in an interview with state broadcaster CCTV. “The course of disease could last 30 to 50 days for some patients,” Wu said. “The virus could take longer to manifest itself in patients with weak immunity, who are also prone to ‘ons’ and ‘offs’ of symptoms.” He sought to reassure citizens that the new cases did not represent a new wave of the pandemic. “There will not be a new minor peak,” Wu said. “We have had the epidemic under control after more than three months of efforts and accumulated considerable experience in both diagnosis and [epidemic] notification. Therefore, we will not allow scattered cases to develop into massive outbreaks.” Firass Abiad, who oversees coronavirus efforts at the Rafik Hariri University Hospital in Beirut, Lebanon’s main government hospital, said a country’s success will depend less on how it curtails the spread of disease during a lockdown than on how the country manages the inevitable resurgence after lockdowns end. “A lockdown is a means and not an end,” he said. “It’s a means either to allow you to regain control or put measures in place to control coronavirus when it comes back. When we eased the lockdown, we knew there would be an increase in the number of cases.” Lebanese government officials said the lockdown was being reimposed for four days starting at midnight Wednesday to allow the authorities time to conduct contact tracing and isolation for several new clusters that have broken out in different parts of the country. They represent 104 cases in the past four days, a big jump in a small country after infections had stabilised at the rate of one or two new cases a day. Most are linked to some of the thousands of Lebanese who have been repatriated in recent weeks from around the world, said Souha Kanj, who heads the infectious diseases department at the American University of Beirut. All the returnees are tested for the coronavirus and required to quarantine for two weeks even if they are negative. But some have not been adhering to the requirement, she said, citing the case of a man who returned from Nigeria and then held a party for his relatives, infecting at least 10 of them. One was a member of the security forces, who has in turn infected a dozen or so of his colleagues. There may also be cases of renewed local transmission, perhaps stemming from people who were asymptomatic but have been silently spreading the disease, Abiad said. Lebanese released from nearly six weeks of lockdown last month have surged onto the streets, openly defying some of the continued restrictions and social distancing rules that remain in force. Similar scenes have occurred in other countries that are ending closures. Crowds of Parisians gathered on the banks of the Seine to toast their release Monday from six weeks of one of the world’s toughest confinements, prompting police on Tuesday to ban the consumption of alcohol in the vicinity of the river. “In any country where people don’t adhere to social distancing, this is going to happen. You are going to have a surge in cases for sure,” Kanj said. Correction: A line in the story about the increase of cases in France was removed because it referred instead to fatalities. https://www.washingtonpost.com/ kalip
  13. coronavirus attacks the entire body — damaging the brain, kidneys and more While the coronavirus is known to cause deadly respiratory problems, research is showing the multitude of ways the disease can ravage the entire body. Through a growing number of studies, reports and doctors’ experiences, the deadly virus has been linked to issues in everything from the brain to the toes. Here is a breakdown of the ways COVID-19 can affect different parts of the body: Eyes The coronavirus has been observed to turn eyes red, causing pinkeye, or conjunctivitis, in some patients. Physicians have suggested that the condition develops in the severely ill, and one study of 38 hospitalised patients in Hubei, China, found that a third had pinkeye. Brain Neurological symptoms such as dizziness, headaches, impaired consciousness and skeletal-muscle injuries have been documented among cases. Chinese doctors in April published a study on nervous system function in the Journal of the American Medical Association that found that patients can also experience more serious issues — including seizures and stroke, which occurs when a blood clot reaches the brain, according to the Wall Street Journal. Heart Doctors have seen alarming cases of myocarditis — an inflammation of the heart muscle — in addition to irregular heart rhythms that can lead to cardiac arrest in coronavirus patients, according to the Washington Post. “They seem to be doing really well as far as respiratory status goes, and then suddenly they develop a cardiac issue that seems out of proportion to their respiratory issues,” Mitchell Elkind, a Columbia University neurologist and president-elect of the American Heart Association, told the outlet. Sensory system The loss of the ability to taste and smell has emerged as a peculiar symptom strongly associated with the virus. The condition, which is known as anosmia, was not initially recognized as a symptom of the virus, but data from a symptom-tracking app in one study found that 60 percent of people who tested positive reported losing their senses of smell and taste, according to researchers from King’s College London. About a quarter experienced the strange symptom before developing other conditions, suggesting it may be an early sign of the virus. Blood The coronavirus also causes blood thickening and clots in the veins, according to doctors. The clots can break loose and travel to the lungs and brain, potentially causing a deadly condition known as pulmonary embolism. It’s still not known why the virus causes the blood clots to form, or why the body is unable to break them up. Gastrointestinal system Digestive issues such as diarrhoea, vomiting and abdominal pain have been among the chief complaints of many patients. Nearly half of the virus patients admitted to the hospital in the central Chinese province of Hubei, where the outbreak occurred, reported experiencing digestive problems, according to a study published in the American Journal of Gastroenterology. Kidneys Kidney damage has been reported among hospitalised patients, with an alarming percentage who require dialysis. Nearly half of hospitalised patients have blood or protein in the urine, suggesting there is early damage to the kidneys, one nephrologist told the Washington Post. And early data showed that between 14 and 30 percent of intensive care patients in New York and Wuhan, China, lost kidney function and required dialysis or continuous renal replacement therapy, according to the report. Feet Foot sores nicknamed “COVID toes” have been documented as an odd symptom linked to the virus. Physicians have observed the purple foot sores, which are similar to those of chickenpox or measles, among mostly young coronavirus patients in Italy, France and Spain. Immune system Physicians have found in some cases that a patient’s immune system goes into overdrive to fight the infection. The response, which is known as “cytokine release syndrome,” can cause damage that results in severe inflammation and organ failure, NPR reported. Lungs COVID-19 is well known to cause coughing, trouble breathing and, in some cases, severe pneumonia. The infection can work its way into the lungs, filling tiny air sacs with cells and fluid that prevent the flow of oxygen, the Guardian reported. When the air sacs become inflamed, pneumonia can develop in the lungs, which then struggle to get enough oxygen to the bloodstream — reducing the body’s ability to take in oxygen and get rid of carbon dioxide, according to the outlet. Ultimately, this can lead to death in severe cases, the outlet said. https://nypost.com/coronavirus/ kalip
  14. FDA Approves Drug for Heart Failure The FDA has approved a new use for the drug dapagliflozin (Farxiga) -- to reduce the risk of a hospital stay or death in people who have a type of heart failure. People with heart failure are more likely to get complications and early death, even when they take other drugs for heart disease such as ACE inhibitors, beta-blockers, and angiotensin receptor blockers. Farxiga's new approval is to treat heart failure with reduced ejection fraction, which means the left ventricle, or lower chamber, of the heart is too weak to pump blood out to the body very well. “Heart failure is a serious health condition that contributes to one in eight deaths in the U.S. and impacts nearly 6.5 million Americans,” Norman Stockbridge, MD, PhD, director of the Division of Cardiology and Nephrology in the FDA’s Centre for Drug Evaluation and Research, says in a news release. The approval is good news for people with heart failure, says Wilson Tang, MD, a heart failure specialist and director of heart failure research at Cleveland Clinic's Heart & Vascular Institute. "This is an area where we have had few significant landmark studies and approvals over the past decade." Farxiga belongs to a class of diabetes drugs called sodium-glucose cotransporter-2 (SGLT2) inhibitors, which also includes canagliflozin (Invokana), empagliflozin (Jardiance), and ertugliflozin (Steglatro). All four drugs are already FDA-approved to treat type 2 diabetes. They lower blood sugar by stopping the kidneys from absorbing extra sugar in the urine back into the blood. In October 2019, the FDA also approved Farxiga to reduce the risk of a hospital stay for heart failure in people with type 2 diabetes plus heart disease, or risks for heart disease. Discovery of a Heart Failure Benefit Researchers discovered the benefits of SGLT2 inhibitors for treating heart failure somewhat by accident, while studying the effects of these drugs in people with type 2 diabetes. In four large studies, people with type 2 diabetes who took an SGLT2 inhibitor were 25% to 35% less likely to be hospitalized for heart failure -- whether or not they had heart failure at the start of the study. Heart failure is an early and the most common heart-related complication in people with diabetes. The new approval is based in part on a study called DAPA-HF, which was the first to look at the effects of an SGLT2 inhibitor specifically on heart failure. This study randomly assigned more than 4,700 people who had heart failure to take Farxiga or an inactive pill (placebo) along with their regular heart failure drugs. After just over 18 months, when Farxiga was added to other heart failure medications, there was an 18% decrease in the risk of death from heart disease and a 17% lower risk of death from all causes. The drug also led to a 26% combined lower risk for a hospital stay due to heart failure, worsening heart failure, or heart-related death. The drug slowed heart failure from getting worse in people both with and without diabetes. How Does It Treat Heart Failure? "That's a great question. No one's 100 percent sure. There are lots of different theories," says Deepak Bhatt, MD, executive director of interventional cardiovascular programs at the Brigham and Women's Hospital Heart & Vascular Centre. (Bhatt has received funding from AstraZeneca, Farxiga's maker, as well as from Sanofi-Aventis, for his research on SGLT2 inhibitors.) "The simplest theory is that it's just a really good diuretic -- a medicine that removes fluid from the body," he says. "People with heart failure are often on a diuretic, also called a water pill, to get extra fluid out of their body." As the drug removes sugar from the urine, it also flushes out salt and fluid. It's likely that other mechanisms are also involved. The drug might increase ketone bodies -- chemicals our bodies make when they break down fats to use for energy. Ketones might improve the heart's energy usage. Or Farxiga and other drugs like it might protect heart muscle cells from more damage. Bhatt says it will take some time and further research to figure out exactly how Farxiga works to treat heart failure. "I think it could take years to sort it all out." Side Effects Genital yeast infections, dehydration, and urinary tract infections (UTIs) are the most common side effects, which happen as Farxiga puts extra sugar into the urine. "When urine has more glucose, there is a higher likelihood for patients to get a UTI," says Tang. Your doctor can check you for these infections if you take Farxiga, and treat you with an antifungal or antibiotic drug if you need it. You may not be able to take Farxiga if you have severe kidney disease or you're on dialysis, because it could affect how your kidneys work. Your doctor might do tests to check how well your kidneys are working while you're on this drug if you: Have kidney problems Have low blood pressure Take diuretics to treat high blood pressure Farxiga can cause serious cases of necrotizing fasciitis of the genital area (Fournier’s gangrene) in people with diabetes and low blood sugar when combined with insulin. SGLT2 Drugs for Heart Failure The big challenge now is for cardiologists to figure out when to prescribe this together with several other drugs in their appropriate doses for their patients with heart failure, Tang says. "This always happens with new drug indications, particularly when the drug cost can be relatively high.” A month's supply of Farxiga for diabetes costs $492. AstraZeneca expects the price to remain the same for heart failure treatment. The company says the amount people actually pay for the drug will depend on their health insurance coverage, their doctor, and any drug assistance programs or savings programs they use. A remaining question is whether other SGLT2 drugs will also help people who have heart failure. Studies are underway to figure that out. These trials may also shed some light on exactly how this group of drugs works to treat heart failure, and whether they're as effective in people with the other type of heart failure. https://www.webmd.com/heart-disease kalip
  15. I saw it on amazon and walmart but you should get at at health food stores
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